Crystal doping aided by rapid expansion of supercritical solutions
نویسندگان
چکیده
منابع مشابه
Modeling and Simulation of Rapid Expansion of Supercritical Solutions
Rapid expansion of supercritical solution (RESS) is a promising technique for microparticle production. The literature points out that the RESS technique can be applied to process a wide range of materials including ceramics, polymers, biopolymers, pharmaceutics, and organic compounds. In order to achieve an adequate understanding of the RESS process, it is necessary to conduct more comprehensi...
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Dissolution pressure and nozzle temperature effects on particle size and distribution were investigated for RESS (Rapid Expansion of Supercritical Solution) process. Supercritical CO2 was used as solvent and Ibuprofen was applied as the model component in all runs. The resulting Ibuprofen nano-particles (about 50 nm in optimized runs) were analyzed by SEM and laser diffraction pa...
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Supercritical carbon dioxide has currently received a lot of attention as attractive media for the production of small and solvent-free particles. Rapid expansion of supercritical solutions (RESS) technique has been paid much attention and has been expected as an effective and environmentally friendly nanoparticle design method. In this study, the production of nanoparticles of RS-(±)-ibuprofen...
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The particle sizes of pharmaceutical substances are important for their bioavailability. Bioavailability can be improved by reducing the particle size of the drug. In this study, artemisinin was micronized by the rapid expansion of supercritical solutions (RESS). The particle size of the unprocessed white needle-like artemisinin particles was 30 to 1200 μm. The optimum micronization conditions ...
متن کاملdrug nano-particles formation by supercritical rapid expansion method; operational condition effects investigation
dissolution pressure and nozzle temperature effects on particle size and distribution were investigated for ress (rapid expansion of supercritical solution) process. supercritical co2 was used as solvent and ibuprofen was applied as the model component in all runs. the resulting ibuprofen nano-particles (about 50 nm in optimized runs) were analyzed by sem and laser diffraction particle size ana...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2002
ISSN: 1530-9932
DOI: 10.1208/pt030429